How long does HRT stay in your system after stopping

HRT Withdrawal: How long does HRT stay in your system after stopping?

Written and Reviewed by Dr. Uzma Qureshi
Published on: 09/06/2024
How long does HRT stay in your system after stopping

Are you feeling better since you started taking hormone replacement therapy (HRT)? Perhaps you no longer experience those bothersome hot flashes and night sweats, and your level of fatigue has decreased. That is truly remarkable. This sense of wellness can make you feel like you should discontinue HRT. but a pressing question remains: “How long does HRT stay in your system after stopping?”

Many females on HRT are curious about this. Just like you, they are thinking about what to do next to stay healthy. Let’s figure it out. This blog will walk you through HRT, its benefits and withdrawal safety.

What is HRT? 

Hormone replacement therapy is a medical treatment where your body’s hormonal imbalance is treated by providing you with hormones that you may be lacking. The goal of this intervention is to control unpleasant symptoms like hot flashes, night sweats, mood swings, and menopausal hair loss. Moreover, maintaining hormonal balance via HRT has proven to keep your bones strong and reduce the risk of fracture. We still have to find out how long HRT stay in your system after stopping. 

Why Should I Consider Taking Hormone Replacement Therapy?

Hormone replacement therapy is an effective treatment option to reduce symptoms of menopause. Always talk to your doctor about your health concerns so they can better guide you. 

You can consider taking HRT if you want to reduce or prevent these Menopausal Symptoms:

  • Moderate to severe hot flashes
  • Night sweats
  • Vaginal dryness
  • Vaginal itching
  • Discomfort, burning or pain during sex
  • Hair loss
  • Bad mood swings.
  • Osteoporosis (bone loss)

When Should I Consider Stopping HRT?

There is no fixed timeline. As everyone experiences HRT differently, the stopping point will always be different. If those symptoms of hormonal imbalance have subsided to a manageable level, you may consider stopping HRT. It’s crucial to discuss with your doctor when to stop taking hormone replacement therapy.

The North American Menopause Society advises only using HRT for five years or less. Because its long-term use has some side effects, like stroke and heart disease,. 

Ultimately, the decision to quit HRT should be based on a thorough discussion with your doctor. They will weigh the risks and benefits, considering your health preferences and needs. 

Is It Safe To Stop HRT?

It is safe for you to quit HRT gradually. Never stop abruptly or suddenly. It is essential to do it under the guidance of your doctor. They can help you taper off the medication gradually to minimise the side effects or withdrawal symptoms. Your doctor’s monitoring will make sure that you are transitioning off HRT in the safest way possible for better health outcomes. 

How Long Does HRT Stay In Your System After Stopping?

It’s never possible for any medication to leave your blood overnight. Now that you have learned the withdrawal story, it’s time to discover, How long HRT stay. The answer is that it varies from person to person. Research suggests that oestrogen levels decrease rapidly after discontinuing HRT, with a continuous decline observed over several days to weeks. HRT’s duration in your system varies widely among individuals. Factors such as metabolism, dosage, and therapy duration influence how long it remains in your body after cessation. While some individuals may eliminate HRT within a few days to a few weeks, others may require more time.

What are the Side Effects of Stopping HRT Suddenly?

Stopping suddenly can cause temporary HRT withdrawal symptoms, like the return of menopause symptoms like hot flashes, night sweats, mood changes and vaginal dryness or itching. You may find all of these withdrawal symptoms unpleasant. These withdrawal effects can occur due to a fast drop in oestrogen levels, which is sometimes referred to as ‘cold turkey menopause’.

How Can I Safely Stop HRT?

To stop HRT safely, you have to work closely with your doctor, as they will create a gradual tapering plan. The treatment that you have been taking for years can never be stopped suddenly. For HRT, it is usually recommended that you slowly decrease your oestrogen dose. It may take a week or three to six months for your body to adjust to lower oestrogen levels and accept the change. This gradual change will help you minimise the likelihood of any drastic changes or side effects of its withdrawal. 

Can I Restart HRT After Stopping?

Yes, if you are finding it difficult to manage your symptoms after quitting HRT, you can restart it. According to the NHS UK, if your symptoms persist for several months after stopping HRT, and especially if they are severe, it may be necessary to restart the treatment. Typically, it will be restarted at lower dosages. 

Moreover, a study conducted in 2017 suggests that restarting adjuvant hormone therapy for breast cancer patients has better outcomes. 


In conclusion, HRT can help you feel better when you have symptoms like hot flashes and mood swings. It can also prevent bone loss and other problems. But it’s essential to know when and how to stop if you need to. It’s safe to stop HRT, but it’s important to do it gradually, not all at once. Your doctor can help you do this safely. Then, for your question, ‘How long does HRT stay in your system after stopping?’ we discussed that HRT stays in your system for different amounts of time, depending on factors like your metabolism and how long you’ve been taking it.

If you need to, you can restart HRT after stopping, but in lower doses if possible. Your doctor can help you decide if this is the right choice for you and help you start menopause treatment again safely. Remember, everyone’s experience with HRT is different, so it’s important to talk to your doctor about what’s best for you.


  1. How long does HRT stay in your system after stopping suddenly?

If you stop HRT suddenly, the duration for which it stays in your system can vary. Generally, HRT can leave your system within a few days to a few weeks after stopping, depending on factors such as the type of HRT, your metabolism, and how long you’ve been taking it.

  1. What happens if I stop HRT suddenly?

If you stop HRT suddenly, you may experience temporary withdrawal symptoms. These symptoms can include the return of menopausal symptoms such as hot flashes, night sweats, mood changes, and vaginal dryness or itching.

  1. Will I lose weight if I stop HRT?

Research indicates that stopping HRT is unlikely to result in weight loss. Weight fluctuations may occur due to factors like ageing or menopause, but they are not necessarily linked to HRT usage.

Connect with Us

My:Skyn is an all female run clinic. We speak both Urdu and Punjabi if you require.

Recent Posts

Aesthetics Awards 2023
Care Quality Commission
General Medical Council
Ace Group
Hamilton Fraser
Cosmetic Redress Scheme
Royal College of Surgeons
General Pharmaceutical Council